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Autonomic function, postprandial hypotension and falls in older adults at one year after critical illness
Yasmine Ali Abdelhamid, Luke M Weinel, Seva Hatzinikolas, Matthew Summers, Thu Anh Ngoc Nguyen, Palash Kar, Liza K Phillips, Michael Horowitz, Adam M Deane, Karen L Jones
Crit Care Resusc 2020; 22 (1): 53-62
- Yasmine Ali Abdelhamid 1, 2, 3
- Luke M Weinel 1, 4
- Seva Hatzinikolas 5
- Matthew Summers 1, 4
- Thu Anh Ngoc Nguyen 1
- Palash Kar 1, 4
- Liza K Phillips 5, 6, 7
- Michael Horowitz 5, 6, 7
- Adam M Deane 1, 2, 3
- Karen L Jones 5, 6, 7
OBJECTIVE: Postprandial hypotension occurs frequently in older survivors of critical illness at 3 months after discharge. We aimed to determine whether postprandial hypotension and its predictors — gastric dysmotility and cardiovascular autonomic dysfunction — persist or resolve as older survivors of critical illness recover, and whether postprandial hypotension after intensive care unit (ICU) discharge is associated with adverse outcomes at 12 months.
DESIGN: Prospective observational study.
SETTING: Tertiary medical–surgical ICU.
PARTICIPANTS: Older adults (aged > 65 years) who had been studied 3 months after ICU discharge and who returned for a follow-up study at 12 months after discharge.
MAIN OUTCOME MEASURES: On both occasions after fasting overnight, participants consumed a 300 mL drink containing 75 g glucose, radiolabelled with 20 MBq 99mTcphytate. Blood pressure, heart rate, blood glucose concentration and gastric emptying rate were measured concurrently before and after ingestion of the drink. Falls, quality of life, hospitalisation and mortality rates were also quantified.
RESULTS: Out of 35 older adults studied at 3 months, 22 returned for the follow-up study at 12 months. Postprandial hypotension was evident in 29% of participants (95% CI, 14–44%) at 3 months and 10% of participants (95% CI, 1–30%) at 12 months. Postprandial hypotension at 3 months was associated with a more than threefold increase in the risk of falls in the year after ICU discharge (relative risk, 3.7 [95% CI, 1.6–8.8]; P = 0.003). At 12 months, gastric emptying was normal (mean time taken for 50% of gastric contents to empty, 101.6 [SD, 33.3] min) and cardiovascular autonomic dysfunction prevalence was low (9% [95% CI, 1–29%]).
CONCLUSIONS: In older adults who were evaluated 3 and 12 months after ICU discharge, postprandial hypotension at 3 months was associated with an increased risk of subsequent falls, but the prevalence of postprandial hypotension decreased with time.
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Both autonomic dysfunction and gastric dysmotility may result in a clinically relevant postprandial fall in blood pressure known as postprandial hypotension. 5
Given that increasing numbers of older patients are admitted to intensive care units (ICUs) worldwide 10
This longitudinal study was designed to assess whether postprandial hypotension and its clinical predictors, gastric dysmotility and cardiovascular autonomic dysfunction, persist or resolve as older survivors of critical illness recover. The primary aim of this study was to estimate the prevalence of postprandial hypotension in a cohort of older survivors at 12 months after ICU discharge. Secondary aims were: to compare the prevalence of postprandial hypotension, orthostatic hypotension and cardiovascular autonomic dysfunction at 3 and 12 months after ICU discharge; to determine whether there is a change in gastric emptying over this period; and to evaluate the effect of postprandial hypotension at 3 months on quality of life and the risk of falls, hospitalisation and mortality in the year after ICU discharge
Study design and participantsThis was a prospective observational study. The methods have been described in detail previously. 13
Study protocolThe protocol was prospectively registered (ACTRN12616000303448) and approved by the Royal Adelaide Hospital Research Ethics Committee. All participants provided written informed consent. Demographic and health data were extracted from the participants’ medical records.
On the day of the study, each participant had fasted from solids and liquids for 12 hours, but had taken their usual medications with a sip of water. 14
Blood pressure and heart rateSeated systolic BP (SBP), diastolic BP (DBP) and heart rate (HR) were measured using an automated oscillometric monitor (DINAMAP ProCare 1000, GE Medical Systems, Waukesha, WI, USA) at 3-minute intervals from t = -9 minutes until t = 240 minutes. Baseline seated BP and HR values were calculated as the mean of three consecutive measurements during the rest period (t = -9, -6 and -3 min). 13
Orthostatic hypotension and autonomic nerve functionAll participants underwent standardised cardiovascular autonomic reflex tests using ANX 3.0 Autonomic Nervous System monitoring technology (ANSAR Group, Philadelphia, PA, USA) as previously described. 13
Gastric emptyingGastric emptying was measured by scintigraphy (e.cam gamma camera, Siemens, Knoxville, TN, USA). 17
Blood glucoseBlood glucose concentration was measured at 15-minute intervals, commencing immediately before ingestion of the glucose drink, using a portable glucometer (MediSense Optium, Abbott, Abbott Park, IL, USA).
Postprandial hypotension symptoms, frailty, functional status, quality of life and health care resource useIn the absence of a validated questionnaire to define symptoms associated with postprandial hypotension (eg, dizziness, fainting, falls), a series of specific questions were developed (Online Appendix 2). 13
Statistical analysisData are presented as mean (standard deviation), if normally distributed, or median (interquartile range), if skewed. Prevalence data are presented as percentage (95% confidence interval [CI]). BP and HR were analysed as changes from baseline (mean of three fasting measurements), while gastric emptying data and blood glucose concentrations were analysed as absolute levels. The incremental area under the curve (iAUC) (area above baseline) was calculated for HR, and the inverse iAUC (area below baseline) was calculated for SBP and DBP for t = 0–60 minutes and t = 0–120 minutes. EQ-5D-5L scores were dichotomised and expressed as counts and percentages for when a score other than Level 1 (no problems) was reported by participants for each of the five dimensions. The EQ-5D-5L VAS data are presented as median (IQR).
Differences in baseline SBP, maximum fall in SBP, maximum rise in HR, autonomic dysfunction score, peak blood glucose concentration, gastric emptying T50 and iAUCs for BP and HR between 3 and 12 months were analysed with paired t tests. Prevalence values for postprandial hypotension, orthostatic hypotension and autonomic dysfunction were compared between 3 and 12 months after ICU discharge with the McNemar exact test. The relationships between postprandial hypotension at 3 months and quality of life, falls, hospitalisation and mortality in the year after ICU discharge were assessed with logistic regression; these results are presented as relative risks (RRs) and 95% CIs. The difference in EQ-5D-5L VAS scores was assessed with the Mann–Whitney test and presented as the Hodges–Lehmann median difference and 95% CI. All analyses were performed using SPSS 24.0 (IBM Corporation, Armonk, NY USA). A P value < 0.05 was considered statistically significant. All physiological data are presented only for the participants attending the study visit at 12 months with no imputation for missing data. Data regarding quality of life, falls, and health care resource use are presented for the whole longitudinal study cohort of 35 patients.
ResultsOf the original cohort of 35 patients, 13 (37%) participants did not attend the 12-month follow-up (Figure 1). All participants who were alive but could not return in person at 12 months were willing to complete questionnaires by telephone. Characteristics of the 22 participants who were studied at 12 months are provided in Table 1. Characteristics of the whole cohort of 35 participants are provided in the Online Appendix3 (Table S1). The participants’ physiological data at 3 months after ICU discharge have previously been published 13
Baseline seated BP measurements were unavailable for one participant. As this participant completed all other aspects of the study, their data were included for analysis of gastric emptying and autonomic dysfunction, but not for assessment of postprandial hypotension. This participant did not have postprandial hypotension at 3 months after ICU discharge.
Postprandial hypotensionChanges in SBP, DBP and HR during the 4 hours after ingestion of the glucose drink are presented (Figure 2 and Online Appendix 3, Table S2). Two of the 21 participants studied (10%; 95% CI, 1–30%) had postprandial hypotension at 12 months, neither of whom reported symptoms in the 12 months since ICU discharge. Neither of these participants had a history of diabetes or elevated blood glucose concentrations during the study days that would indicate diabetes. One of these participants also had postprandial hypotension at 3 months and was taking stable doses of medications for hypertension (angiotensin-converting enzyme inhibitor and β-blocker).
Of the ten participants diagnosed with postprandial hypotension at 3 months after ICU discharge, four were lost to follow-up — one had died and three were unable to attend due to ongoing illness. Five of the six remaining participants who attended both study days had postprandial hypotension at 3 months but not at 12 months. Only one of these participants had a reduction in prescribed antihypertensives or diuretics between 3 and 12 months (cessation of angiotensin-converting enzyme inhibitor). Furthermore, the sustained SBP fall observed in the 2 hours following ingestion of the glucose drink in the cohort at 3 months was not evident at 12 months (inverse iAUC 0–60 min, 461  v 259  mmHg.min, respectively [P = 0.049]; inverse iAUC 0–120 min, 1064  v 508  mmHg.min, respectively [P = 0.01]) (Figure 2, panel A). The maximum fall in SBP following ingestion of the drink was also greater at 3 months than at 12 months following ICU discharge (-28  v -20  mmHg; P = 0.02).
Autonomic nerve function and orthostatic hypotensionTwo participants (9%; 95% CI, 1–29%) had cardiovascular autonomic dysfunction at 12 months, and both also had orthostatic, but not postprandial, hypotension. Neither of these participants had cardiovascular autonomic dysfunction at 3 months. The mean maximal orthostatic falls in SBP and DBP for the whole cohort were -8 (21) mmHg and -6 (9) mmHg, respectively. There were no significant differences in the prevalence of orthostatic hypotension, prevalence of cardiovascular autonomic dysfunction or cardiovascular autonomic dysfunction scores between 3 and 12 months (Table 2).
Gastric emptyingGastric emptying of the glucose drink approximated a linear pattern after a brief lag phase of 1.3 (1.5) minutes (Figure 3). The mean gastric emptying T50 was 101.6 (33.3) minutes at 12 months, which was not different to that at 3 months (T50, 103.4 [28.3] min) (P = 0.77).
Blood glucoseMean blood glucose concentration increased from 6.8 (1.8) mmol/L and peaked at 13.7 (3.9) mmol/L (Figure 4) after ingestion of the glucose drink. In nine participants (41% [95% CI, 21–64%]), the blood glucose concentration was greater than 11.0 mmol/L at t = 120 minutes, consistent with a diagnosis of diabetes. 23
Functional status and frailtyAll 22 participants who returned for the study at 12 months were residing at home. Scores on the Katz Index of Independence in Activities of Daily Living, Lawton Instrumental Activities of Daily Living Scale and Clinical Frailty Scale were 5 (1.3), 8 (0.5) and 3 (1.1) respectively. One participant was classified as moderately frail but still independent, six participants as vulnerable but independent, and all other participants as independent and not frail.
Postprandial hypotension as a predictor of falls, quality of life, hospitalisation and mortality in the year after ICU dischargeTwelve (36%) participants reported at least one fall in the 12 months since ICU discharge. The reported number of falls ranged from one to four over this period and one participant had been admitted to hospital due to a fall. Postprandial hypotension at 3 months after ICU discharge was associated with a more than threefold increase in risk of falls in the year after ICU discharge (7/9 [78%] v 5/24 [21%]; RR, 3.7 [95% CI, 1.6–8.8]; P = 0.003).
Quality-of-life scores at 12 months are shown in the Online Appendix 3 (Table S3). Postprandial hypotension at 3 months did not predict an abnormal score in any of the five dimensions of the EQ-5D-5L instrument at 12 months. Similarly, there was no difference in EQ-5D-5L VAS scores between participants without and those with postprandial hypotension at 3 months (Hodges–Lehmann median difference, -10 [95% CI, -20 to 5]; P = 0.185).
Seventeen (49%) participants had been readmitted at least once to an acute care hospital in the year after ICU discharge. Twenty participants (57%) had presented to an emergency department. Eighteen participants (51%) had accessed inpatient or outpatient rehabilitation services in the year after ICU discharge. One participant who had postprandial hypotension at 3 months (10%) and two who did not have postprandial hypotension at 3 months (8%) had died in the year after ICU discharge. Postprandial hypotension at 3 months did not predict readmission to an acute care hospital (6/10 [60%] v 11/25 [44%]; RR, 1.36 [95% CI, 0.7–2.7]; P = 0.37) or mortality (1/10 [10%] v 2/25 [8%]; RR, 1.25 [95% CI, 0.13–12.3]; P = 0.85) in the 12 months after ICU discharge.
Key findingsThe findings of this study indicate that postprandial hypotension, which affected almost a third of this older cohort at 3 months after ICU discharge and was shown to be a predictor of falls, resolves in the year following critical illness. Furthermore, gastric emptying was normal at 3 months after ICU discharge and remained unchanged at 12 months. Cardiovascular autonomic neuropathy was also unexpectedly infrequent in this cohort. To our knowledge, this is the first time that autonomic function and gastric emptying have been measured at 1 year after critical illness.
Despite enrolling a cohort of older ICU survivors who were “relatively well” (ie, alive 3 months after ICU discharge, willing to return to be studied at 12 months, < 50% ventilated during their original ICU admission, and short duration of ICU admission), approximately 20% could not return for the study at 12 months because of illness or death. Also, among those who did return, readmission to hospital had occurred frequently. Nonetheless, all 22 participants who returned for the 12-month study were living independently.
Clinical implicationsThe clinical implications of this study include that a third of the older survivors who were studied reported at least one fall in the year following ICU discharge and that postprandial hypotension was a predictor of falls. There are few data about falls in patients who have experienced critical illness and existing studies have mainly focused on falls in the ICU 24
Relationship to previous studiesIn healthy individuals, ingestion of nutrient is associated with an increase in mesenteric blood flow and concurrent compensatory responses by the autonomic nervous system and cardiovascular system (arterial baroreceptor and gastrovascular reflexes leading to increased cardiac output and peripheral vasoconstriction), such that postprandial BP is maintained despite meal-induced splanchnic blood pooling. 5
As many as 50% of critically ill patients have slow gastric emptying in the ICU, 35
Despite normal gastric emptying and low prevalence of cardiovascular autonomic dysfunction, postprandial hypotension was prevalent in this older cohort at 3 months after ICU discharge. Inferences about the prevalence of postprandial hypotension 12 months after ICU discharge are limited owing to the small size of the cohort, but the magnitude of the fall in systolic BP following ingestion of the glucose drink in the whole cohort was attenuated at 12 months compared with that at 3 months. This is in contradistinction to the increase in prevalence of postprandial hypotension observed in normal ageing. 40
Strengths and limitationsThis study had several strengths, including the longitudinal design with a minimum follow-up period of 12 months after ICU discharge, the use of sophisticated methods (including scintigraphy) and a stringent definition of postprandial hypotension (a sustained fall in SBP of > 20 mmHg for > 30 min). The use of this conservative definition of postprandial hypotension minimised the possibility of false-positive diagnoses. However, there were several study limitations, including small sample size, single-centre design, predominantly male participants and the heterogeneous cohort of older ICU survivors, who had other potential causes of postprandial hypotension and cardiovascular autonomic dysfunction. These causes include age, complications of prolonged hospital admission, and comorbidities such as diabetes. However, none of the participants who had diabetes had postprandial hypotension at 12 months in this study. We do not have information regarding autonomic function or postprandial hypotension before or during the ICU admission for this cohort, so it is difficult to make conclusions about the role of critical illness as a causal factor per se. It is also important to note that about a third of the cohort was lost to follow-up at 12 months after ICU discharge, which is a potential confounder in many longitudinal studies of ICU survivors, 42
ConclusionThis longitudinal, single-centre study suggests that in older survivors of critical illness, postprandial hypotension is prevalent 3 months after ICU discharge and increases the risk of falls in the year following ICU discharge. The prevalence of postprandial hypotension decreases with time in the year after ICU discharge.
Acknowledgements: Kylie Lange, Biostatistician, Centre of Research Excellence in Translating Nutritional Science to Good Health, provided statistical advice and assisted with statistical analysis for the study. Brianna Tascone, Research Scientist, Intensive Care Unit, Royal Melbourne Hospital, helped produce figures for the manuscript. We also acknowledge Radiology SA for donating the Siemens e.cam gamma camera for research purposes.