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Original Article

Prevalence, characteristics, drainage and outcome of radiologically diagnosed pleural effusions in critically ill patients

Davina Bates, Natalie Yang, Michael Bailey, Rinaldo Bellomo

Crit Care Resusc 2020; 22 (1): 45-52

Correspondence: d.bates@alfred.org.au

  • Author Details
    • Davina Bates 1
    • Natalie Yang 2, 3
    • Michael Bailey 4
    • Rinaldo Bellomo 3, 4, 5, 6
    1. Department of Radiology, The Alfred Hospital, Melbourne, VIC, Australia.
    2. Department of Radiology, Austin Hospital, Melbourne, VIC, Australia.
    3. Department of Intensive Care, Austin Hospital, Melbourne, VIC, Australia.
    4. Australian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia.
    5. School of Medicine, University of Melbourne, Melbourne, VIC, Australia.
    6. Data Analytics Research and Evaluation Centre, Austin Hospital and University of Melbourne, Melbourne, VIC, Australia.
  • Competing Interests
    None declared
  • Abstract
    OBJECTIVE: Pleural effusions in the intensive care unit (ICU) are clinically important. However, there is limited information regarding effusions in such patients. We aimed to estimate the prevalence, patient characteristics, mortality, effusion duration, radiological resolution, drainage, and reaccumulation rates of pleural effusions in ICU patients.
    METHODS: This retrospective cohort study assessed all patients admitted to a tertiary hospital ICU from 1 January to 31 December 2015 with a chest x-ray report of pleural effusion. All chest x-ray reports were reviewed and data were combined with an established clinical ICU database. Statistical analysis of the combined dataset was performed.
    RESULTS: Among 2094 patients admitted to the ICU, 566 (27%) had pleural effusions diagnosed by chest x-ray. The effusion median duration was 3 days (IQR, 1–5 days). Radiologically documented clearance of the effusion occurred in 243 patients (43%) and drainage was performed in 52 patients (9%). Among patients with effusion clearance, 80 (33%) reaccumulated the effusion. Drainage was more common in patients who experienced reaccumulation (19% v 7%; P = 0.004). Overall, 89 patients (16%) died, with 20% mortality among those with reaccumulation versus 9% among patients without reaccumulation (P = 0.037).
    CONCLUSION: Pleural effusions are common in ICU patients and drainage is infrequent. One-third of effusions reaccumulate, even after drainage, and one in six patients with an effusion die in hospital. This information helps clinicians estimate resolution rates, advantages and disadvantages of effusion drainage, and overall prognosis.
  • References
    1. DeBiasis E, Puchalski J. Pleural effusions as markers of mortality and disease severity: a state of the art review. Curr Opin Pulm Med 2016; 22: 386-91.
    2. Bintcliffe O, Hooper C, Rider I, et al. Unilateral pleural effusions with more than one apparent etiology. A prospective observational study. Ann Am Thorac Soc 2016; 13: 1050-6.
    3. Maslove D, Chen B, Wang H, Kuschner W. The diagnosis and management of pleural effusions in the ICU. J Intensive Care Med 2013; 28: 24-36.
    4. Azoulay E. Pleural effusions in the intensive care unit. Curr Opin Pulm Med 2003; 9: 291-7.
    5. Mattison L, Coppage L, Alderman D, et al. Pleural effusions in the medical ICU: prevalence, causes and clinical implications. Chest 1997; 111: 1018-23.
    6. Light RW, Macgregor MI, Luchsinger PC, Ball WC. Pleural effusions: the diagnostic separation of transudates and exudates. Ann Intern Med 1972; 77: 507-13.
    7. Eibenberger K, Dock W, Ammann M, et al. Quantification of pleural effusions: sonography versus radiography. Radiology 1994; 191: 681-4.
    8. Volpicelli G, Elbarbary M, Blaivas M, et al. International evidence- based recommendations for point-of-care lung ultrasound. Intensive Care Med 2012; 38: 577-91.
    9. Xirouchaki N, Magkanas E, Vaporidi K, et al. Lung ultrasound in critically ill patients: comparison with bedside chest radiography. Intensive Care Med 2011; 37: 1488-93.
    10. Umbrello M, Mistraletti G, Galimberti A, et al. Drainage of pleural effusion improves diaphragmatic function in mechanically ventilated patients. Crit Care Resusc 2017; 19: 64-70.
    11. Liang SJ, Tu CY, Chen HJ, et al. Application of ultrasound-guided pigtail catheter for drainage of pleural effusions in the ICU. Intensive Care Med 2008; 35: 350.
    12. Thomas R, Jenkins S, Eastwood PR, et al. Physiology of breathlessness associated with pleural effusions. Curr Opin Pulm Med 2015; 21: 338-45.
    13. Fartoukh M, Azoulay E, Galliot R, et al. Clinically documented pleural effusions in medical ICU patients: how useful is routine thoracentesis? Chest 2002; 121: 178-84.
    14. Tu CY, Hsu WH, Hsia TC, et al. Pleural effusions in febrile medical ICU patients: chest ultrasound study. Chest 2004; 126: 1274-80.
    15. Dres M, Roux D, Pham T, et al. Prevalence and impact on weaning of pleural effusion at the time of liberation from mechanical ventilation a multicenter prospective observational study. Anesthesiology 2017; 126: 1107-15.
    16. Chiumello D, Marino A, Cressoni M, et al. Pleural effusion in patients with acute lung injury: a CT scan study. Crit Care Med 2013; 41: 935-44.
    17. Walker SP, Morley AJ, Stadon L, et al. Nonmalignant pleural effusions: a prospective study of 356 consecutive unselected patients. Chest 2017; 151: 1099-105.
    18. Goligher E, Leis J, Fowler R, et al. Utility and safety of draining pleural effusions in mechanically ventilated patients: a systematic review and meta-analysis. Crit Care 2011; 15: R46.
    19. DeBiasi E, Pisani M, Murphy T, et al. Mortality among patients with pleural effusion undergoing thoracentesis. Eur Respir J 2015; 46: 495-502.
Pleural effusions are typically a secondary finding in the critically ill patient and are multifactorial in origin. 1 2 While the aetiologies are broad, the supportive measures specific to the care of critically ill patients are an important causal consideration. These supportive measures include mechanical ventilation, paralysis and sedation, and aggressive fluid resuscitation. 3 Primary causes, such as infection, malignancy, hypoalbuminaemia, trauma, and post-operative pleural inflammation, are not specific to the critically ill patient but remain important aetiologies. 3 4 5

The classic division of effusions into transudates and exudates is based on fluid evaluation (Light’s criteria) and narrows the differential and subsequent treatment goals. Transudative effusions result from systemic factors that increase production or reduce absorption of pleural fluid without capillary injury. The cause can typically be discerned from the patient’s clinical presentation (eg, congestive heart failure, liver failure, hypoalbuminaemia), and intervention is typically directed at the underlying systemic condition. Exudative effusions develop from increased capillary permeability and obstructed lymphatic drainage. The differential is more varied than for transudates, with the most common causes including infection, malignancy, trauma, and gastrointestinal disease. 6

While ultrasound is gaining popularity and is more sensitive and accurate than chest x-ray for identifying a pleural effusion, 7 8 9  routine (and serial) ultrasonography of all intensive care unit (ICU) patients is not readily available. Thus, the chest x-ray remains the first line and readily available diagnostic tool to study the epidemiology of effusions in the ICU. Moreover, comparison of serial chest x-rays is both logistically achievable and helpful in assessing pleural effusion changes over time.

Pleural effusions of unclear cause and effusions requiring culture or cytology are indications for fluid sampling and analysis. This is achieved by needle aspirate or drain insertion (in-dwelling pigtail catheter or chest tube). Drain insertion is preferred, when safe to do so, in order to achieve potential symptomatic relief at the same time. Therapeutic drainage is the other indication for drain insertion and is performed to improve symptoms such as dyspnoea and haemodynamic compromise or eliminate any source of infection. 10 11 12

There is a paucity of data on the prevalence, patient characteristics, duration, radiological resolution, drainage, reaccumulation and associated mortality of pleural effusions in ICU patients. This study highlights how an electronic word search engine facilitates rapid and accurate identification of all chest x-ray reports documenting pleural effusions over a given period. Accordingly, we combined these data with a detailed post-identification review process and ICU clinical database to generate an epidemiological overview of ICU patients with pleural effusions diagnosed by chest x-ray.

Methods

Patients and data collection

This retrospective cohort study was approved by the Austin Hospital Human Research Ethics Committee with waiver for informed consent (reference No. LNR/17/Austin/49).

The study was performed in patients admitted to a tertiary ICU, with a mix of medical and surgical patients. Patients were identified as having a pleural effusion using an electronic word search engine of all chest x-ray reports stored in the Picture Archive Communication System (PACS) research database. The natural language terms “pleural effusion”, “pleural fluid” and “pleural collection” were searched to identify all positive reports of pleural effusion. Reports of “no pleural effusion” were excluded. This analysis was performed for all ICU chest x-ray reports in the 12-month period from 1 January to 31 December 2015.

Pleural effusion clearance was assessed radiologically and recorded if there was a subsequent chest x-ray during the hospital admission documenting no effusion. Post-surgical patients with intercostal catheters inserted at the time of surgery were not included in the effusion drainage group unless there was a new drain inserted after surgery.

Available fluid analysis results of the drained effusions were categorised into transudates and exudates based on Light’s criteria, 6 or as a haemothorax if the red blood cell count exceeded 100 000/µL.

The data extracted from the ICU clinical database included age, gender, length of hospital and ICU stay, Acute Physiological and Chronic Health Evaluation (APACHE) scores, and patient mortality. Data collected in relation to the pleural effusion included duration, clearance of the effusion, drainage, and the presence of reaccumulation during the hospital admission. The data were recorded in a standardised Microsoft Excel spreadsheet and combined with clinical data from an established ICU clinical database.
 

Data analysis

Within the study population, univariate analysis was performed to compare patient characteristics according to survival, effusion clearance, drainage and reaccumulation.

Comparisons were performed using X2 tests for equal proportion, Student t tests for normally distributed data, and Wilcoxon rank sum tests otherwise, with results reported as number and percentages, mean (standard deviation) or median (interquartile range [IQR]) respectively.

Time to effusion clearance was assessed using a log-rank test and presented using Kaplan–Meier survival curves. Independent predictors or mortality were determined using multivariable logistic regression, with results presented as odds ratios (95% confidence interval). The multivariate model was constructed using stepwise selection and backwards elimination techniques considering all available baseline variables before a final assessment of clinical and biological plausibility. To increase the robustness of the prediction model and reported analysis, a two-sided P value of 0.01 was used to indicate statistical significance. All analysis was performed using SAS version 9.4 (SAS Institute).

Results

During the 12-month study period (1 January to 31 December 2015), 2094 patients were admitted to the ICU and 566 patients (27%) had a positive pleural effusion chest x-ray report. The chest x-rays were typically performed erect, with a 7% rate of supine films.
 

Patient and effusion characteristics

The key characteristics of study patients and their effusions are shown in Table 1. Patients with pleural effusions were predominantly male, with a median age of 66 years (IQR, 56–75 years). A similar proportion of patients were admitted to the ICU for medical and surgical reasons. Cardiac surgery, cardiovascular disease, and sepsis were the most common admission diagnoses. Most pleural effusions were not present at admission but developed during the ICU admission. One-third of pleural effusions were bilateral.
 

Patient and effusion outcomes

Pleural effusion and patient outcomes are outlined in Figure 1. Radiological clearance was achieved in 323 patients (57%) — this includes both drained and non-drained effusions. Patients who achieved radiological clearance had a later diagnosis of their effusion, longer ICU and hospital admissions, longer time on mechanical ventilation, and were more likely to receive continuous renal replacement therapy (CRRT). Most effusions cleared during ICU treatment and the median time to clearance was 3 days (IQR, 1–5 days). Mortality was similar to that of patients who did not achieve radiological resolution (Table 2).
 

Pleural effusion drainage

Overall, almost one in ten patients underwent pleural effusion drainage (after exclusion of patients with post-operative intercostal catheters inserted at the time of operation) with a median time from diagnosis to drainage of 7 days (IQR, 2–11 days) (Table 2). All drainage procedures were performed via a chest tube or pigtail drain insertion. Drainage was associated with significantly longer median effusion duration, longer median length of mechanical ventilation and ICU and hospital stay. Effusion confirmation with additional imaging modalities was also more common in the drainage group, as was reaccumulation of the effusion. However, patients who received drainage achieved an overall pleural effusion clearance rate similar to the non-drainage group and time to clearance was also similar (Figure 2). There was a low rate of pleural fluid analysis for the drained effusions (Table 3). Only 19% underwent biochemistry testing and 63% underwent culture and Gram stain. Exudates (excluding haemothorax) were more common than transudates, and haemothorax was twice as common as plain exudates and three times as common as transudates. Only three positive organisms (3%) were identified by culture or Gram stain.
 

Pleural effusion reaccumulation

Reaccumulation occurred in one-third of patients with radiological clearance (Table 2). It was associated with longer median effusion duration, longer duration of mechanical ventilation and longer median ICU and hospital stay. Moreover, CRRT and drainage were both twice as common in patients who reaccumulated their effusion. Median time to reaccumulation was 4 days (IQR, 2–8 days), and mortality was twice as high in patients with reaccumulation.
 

Mortality

A comparison of survivors with non-survivors is presented in Table 4. Non-survivors had higher APACHE III scores, higher serum creatinine and lower trough albumin levels on the day of admission. They experienced longer duration of mechanical ventilation and ICU stay, as well as greater use of CRRT. Finally, non-survivors were more likely to undergo a different imaging modality confirming the pleural effusion and were more likely to have had chest drains in situ at the time of diagnosis. The risk of in-hospital mortality increased by 3% for every one-point increase in the patient’s APACHE III derived risk of death, and more than doubled if the patient underwent CRRT (Table 5). In contrast, elective admissions and radiological clearance of the effusion without drainage were independent predictors of lower in-hospital mortality.

Discussion

We performed an electronically assisted identification of all patients with a chest x-ray report of pleural effusion during their ICU stay. We found that about one in four patients had a pleural effusion diagnosed by chest x-ray; one-third of these effusions were bilateral and two-thirds of such effusions developed during ICU treatment. The majority of effusions failed to achieve clearance at the last available chest x-ray. If clearance was achieved, one-third developed reaccumulation. One in ten effusions was treated with a drainage procedure, at a median of one week (IQR, 2–11 days) after diagnosis, and in about one-third of these patients, the effusion re-accumulated. Finally, one in six patients with an effusion did not survive to hospital discharge.
 

Relationship with previous literature

Prevalence rates for pleural effusions have been highly variable and uncommonly reported in the literature. In 1997, in a study of 100 medical patients 5 which used both x-ray and ultrasound, the prevalence was 62% for mostly small pleural effusions — of which two-thirds were detected at admission. Over a one-year period, French investigators 13 reported that 8.4% of medical ICU patients had a pleural effusion on clinical examination and chest x-ray, with 72% of such patients having a thoracentesis. Among ICU patients in Taiwan, 14 clinical examination, chest x-ray, ultrasound and drainage in 94 febrile medical patients were reported with no overall prevalence of pleural effusion. Using ultrasound, other investigators 15 reported a prevalence of 37% in 136 mechanically ventilated patients, but only and specifically at the time of ventilation liberation. Others 16 reported a much higher rate of pleural effusion (83% of 129 patients) but using computed tomography and only in a cohort with acute respiratory distress syndrome.

Pleural effusions have been associated with increased mortality. Walker and colleagues 17 report one-year mortality rates of 25–50% with newly diagnosed non-malignant effusions, with particular high mortality rates associated with bilateral effusions (57%). The published data on patient outcomes after effusion drainage are also variable and inconsistent. 18 DeBiasi et al 19 described a 30-day mortality of 21% and 11% in 308 patients undergoing drainage of effusions caused by congestive heart failure and infection respectively. No data exist on longitudinal assessment and reaccumulation rates of effusions with or without drainage.
 

Implications of study findings

Our study implies that, in a mixed medical and surgical ICU population, pleural effusions diagnosed by chest x-ray affect a quarter of patients, typically develop while the patient is in the ICU, and are associated with a one in six mortality rate. Moreover, our study implies that most effusions do not achieve radiological clearance and that only a minority are treated with a drainage procedure. Of the effusions that are drained, few undergo complete fluid analysis and are thus typically performed for therapeutic indications. Even after effusion resolution, reaccumulation occurs in one-third of the patients, even in those who receive a drainage procedure. Finally, the association between longer hospital and ICU admissions with effusion drainage and reaccumulation implies these patients are generally very unwell. This information has implications for clinicians tasked with estimating the likely risk, outcome and resolution rates of pleural effusions in ICU patients and considering the advantages and disadvantages as well as the duration of drainage in light of the risk of reaccumulation.
 

Study strengths and limitations

To the best of our knowledge, this is the first study to investigate the prevalence, characteristics, drainage and outcome of pleural effusions in a general university-affiliated ICU in a high income country. This is also the largest study of pleural effusions in the ICU to date, with a study population that is at least double the size of previous studies. Moreover, it is the first study to report on the resolution and reaccumulation rates of such effusions or on the confirmation by other imaging modalities. Therefore, our information provides the first comprehensive description of pleural effusions diagnosed by chest x-ray among critically ill patients.

Our study has several limitations. The use of chest x-ray reports to identify and follow pleural effusions in the ICU has limited sensitivity and specificity compared with ultrasound. However, unlike daily chest x-rays, ultrasound screening of all ICU patients is not usual care and it remains unclear whether a pleural effusion diagnosed on ultrasound and not seen on chest x-ray is clinically important. Secondly, using radiology reports may incur a degree of error without inter-observer confirmation. Taking this into account, the number of effusions may have been underestimated. However, the missed pleural effusions would likely have been small and thus of limited clinical importance. This was only a single site study and without long term follow-up. Moreover, the study was not designed to investigate the cause of the identified pleural effusions. However, it is the first to provide a detailed description of multiple aspects of such effusions, their drainage, and hospital outcome.
 

Conclusion

Pleural effusions diagnosed by chest x-ray affected a quarter of patients in a general academic ICU setting, with associated mortality of one in six patients. Less than half of the effusions achieved radiological resolution, with one in ten achieving resolution only via drainage and one-third re-accumulating. This information is important for clinicians in estimating likely risk, outcome, and resolution rates of such effusion as well as the advantages and disadvantages of drainage.
Acknowledgements: This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.

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